To be honest, I saw Janine as interested in Sherlock Holmes simply because she found him entertaining/interesting to be around.
Apparently I'm the only one who interpreted the "famous Sherlock Holmes" comment as an allusion to whatever John/Mary had told her rather than what she had read in the newspapers. She's supposed to be Mary's closest friend, and the fact that she's the maid of honor suggests that she must have known John/Mary before Mary actually became engaged (and therefore, she knew John/Mary when Sherlock was supposed to be dead). I'm not saying that Mary has been relaying every dirty detail, but "my husband's famous best friend faked his suicide and is now helping with the seating chart" would have come up in conversation.
I actually see some parallels between her and John. She's using Sherlock for entertainment/adreneline purposes in the same way that John does. Obviously Sherlock and John's friendship is on a different level, but still. There's a lovely moment in the first episode where John is openly impressed and Sherlock is rather pleased and says that most people just tell him to piss off. Janine appreciates his talent in the same way, she takes his deductions seriously and jokingly asks if she can "keep him" which is actually quite a compliment because it suggests that she enjoys Sherlock's company (whereas most people decidedly do not).
I got the impression that she liked Sherlock for the same reason we like watching Sherlock. It's interesting/entertaining to watch him "do his thing" so to speak, and time with him is never boring. Within a few hours of meeting him, she's standing there watching him solve a murder case and making jokes about handcuffs. She's just enjoying being a spectator.
And to be honest, I think that given the choice between a) enduring an angry/jilted Janine standing in his hospital room crying dramatically about how she had loved him and b) libel and a truce, I think he would have prefered the first option.