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What do you think Irene's response to Sherlock's death was?
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I think Irene saw through it. Although she didn't know Sherlock well, I think she knew him well enough to know that he's far too in love with himself to commit suicide. It seems plausible to me because she herself has done it before and knows how easy it is to fake your death quite convincingly.
Either that, or she said, "Pity he killed himself before I could seduce him."