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How significant is that pause before "yesterday"? Doesn't it mean John has almost forgotten, or at least, has to think a bit to remember, that he did meet Sherlock only the previous day?
As if life before Sherlock is a distant, or at least blurry, memory.
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It just means he had to stop and think about how long he'd known Sherlock; and given what had taken place so far I think he was also a little surprised that it had been so little time. Nothing really significant in the pause. Just thinking time
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he's so lucky to have meet him.