What I do find interesting is that most people who's played a villanous role in Sherlock, always use predatory/sexual type of intimidaitons (Irene, Moriarty, CAM, CS).
I've always figured it is because that is what works the most on Sherlock, seeing as regular insults or threats doesn't really bother him much. But he is more intimidated by anything sexual, and those types of villains pick up on that, so it becomes a tool in their power play.