"There are lives at stake, Sherlock! Actual human lives. Just so I know, do you care about that at all?" - "Will caring about them help to save them?" - "Nope" - "Then I continue NOT to make this mistake." - "And you find that easy, do you?" - "Yes, very. Is that news to you?" - "No... no." - "I've disappointed you." - "That's a good - good deduction. Yeah." - "Don't make people into heroes, John. Heroes don't exist and if they did I wouldn't be one of them."
(Okay, we had the last sentence already but I also like the part that comes before ;))
"I'll burn you. I'll burn the heart out of you." - "I have been reliably informed that I don't have one." - "But we both know that's not quite true."
"Without you I get hung for this!" - "No, no, not at all... hanged, yes."
"I heard you were somewhere getting shot at. What happened?" - "I got shot."
"Look at those cheekbones, I could cut my hand slapping that face."
"Say that again! Say that again and know that if you are lying to me, I will find you and then I will ssssskin you.."
"Oh, don't do that." - "Do what?" - "You being all mysterious with your... cheekbones and turning your coat collar up so you look cool."
"You look sad... when you think he can't see you. Are you okay? Don't just say you are, because I know what that means, looking sad when you think no one can see you." - "You can see me." - "I don't count."
"One day we'll be standing around a body and Sherlock Holmes will be the one who put it there." - "Why would he do that?" - "'Cause he's a psychopath. Psychopaths get bored."
"Moriarty is playing with your mind too. Can't you see what's going on!" - "No, I know you're for real." - "One hundred percent?" - "...nobody can fake being such an annoying dick all the time."
"Alone is what I have, alone protects me." - "No - friends protect people!"
"You... machine!"
"The name's Sherlock Holmes and the address is 221b Bakerstreet!"
"Not our division!"
"Yeah well you know what he's like. CSI: Baker Street."
"Why's it always the hat photograph?" - "Bachelor John Watson." - "Why kind of hat is it anyway?" - "Bachelor. What the hell are they implying?" - "Is it a cap - why's it got two fronts?" - "It's a deerstalker. Frequently seen in the company of bachelor John Watson..." - "How do you stalk a deer with a hat? What are you going to do, throw it?" - "Confirmed bachelor John Watson." - "Some sort of death frisbee?"